Scientists from the Indian Association for the Cultivation of Science (IACS) in Kolkata have identified a potential new cancer therapy target by activating the DNA repair enzyme Tyrosyl-DNA phosphodiesterase 1 (TDP1).
Their study shows that cancer cells survive chemotherapy by using TDP1 to repair DNA damage caused by Topoisomerase 1 (Top1) inhibitors, such as Camptothecin. The enzyme Cyclin-dependent kinase 1 (CDK1) enhances this repair process by phosphorylating TDP1, which is crucial for cancer cell survival during treatment. The researchers propose that combining CDK1 inhibitors with Top1 inhibitors could overcome drug resistance, offering a more effective cancer treatment. Further studies are being conducted to validate this approach.
Source : https://pib.gov.in/PressReleasePage.aspx?PRID=2063775
