Scientists at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) have discovered a novel method to detect and develop diagnostic tools for the Monkeypox virus (MPV). They identified and characterized G-quadruplex sequences (GQs) within the MPV genome, which are unique nucleic acid structures absent in other pox viruses, pathogens, or the human genome.
This discovery holds potential for creating diagnostic tools and antiviral therapies, as these GQs can be targeted using small-molecule fluorescent probes. The Ministry of Science and Technology emphasized that this work is significant given the global concerns about MPV’s unanticipated spread, unclear transmission modes, and symptoms. The research offers valuable insights into MPV virology and aids in developing diagnostic and therapeutic interventions.
